Genes involved in human sialic acid biology do not harbor signatures of recent positive selection

نویسندگان

  • Jiyun M. Moon
  • David M. Aronoff
  • John A. Capra
  • Patrick Abbot
  • Antonis Rokas
چکیده

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Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology

Sialic acids are nine carbon sugars ubiquitously found on the surfaces of vertebrate cells and are involved in various immune response-related processes. In humans, at least 58 genes spanning diverse functions, from biosynthesis and activation to recycling and degradation, are involved in sialic acid biology. Because of their role in immunity, sialic acid biology genes have been hypothesized to...

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Examination of signatures of recent positive selection on genes involved in human sialic

20 Sialic acids are nine carbon sugars ubiquitously found on the surfaces of vertebrate cells 21 and are involved in various immune response-related processes. In humans, at least 58 genes 22 spanning diverse functions, from biosynthesis and activation to recycling and degradation, are 23 involved in sialic acid biology. Because of their role in immunity, sialic acid biology genes have 24 been ...

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تاریخ انتشار 2017